General Medicine PG Thesis Topics: Top 100 Research Ideas 2026

General Medicine PG thesis topics span the widest range of any clinical specialty — from lifestyle diseases like diabetes and hypertension to tropical infections, organ-specific disorders, and multisystem conditions. Choosing the right MD General Medicine thesis topic is critical: it must be feasible within your 3-year residency, relevant to your patient population, and generate results that contribute to clinical practice. This comprehensive list of 100 research-worthy topics will help you identify a topic aligned with your interest and your institution's case load.

1Why General Medicine Research Matters in 2026

General Medicine — also called Internal Medicine — is the broadest clinical specialty, and its research touches every system of the body. MD General Medicine students have a unique advantage: the sheer volume and diversity of cases in a tertiary medicine ward provides rich material for prospective cohort studies, case-control studies, and clinical audits. With India's rising burden of non-communicable diseases alongside persistent infectious disease challenges, General Medicine research has never been more relevant.

2Diabetes & Metabolic Disorders Thesis Topics (1–20)

1. HbA1c variability as a predictor of cardiovascular complications in Type 2 diabetes mellitus
2. Prevalence and risk factors of diabetic peripheral neuropathy in newly diagnosed T2DM patients
3. Correlation between microalbuminuria and cardiovascular risk in T2DM: a cross-sectional study
4. Diabetic ketoacidosis (DKA): clinical profile, precipitating factors, and outcomes in a tertiary centre
5. Hyperglycaemic hyperosmolar state (HHS): clinical presentation, management, and mortality predictors
6. Non-alcoholic fatty liver disease (NAFLD) in T2DM: prevalence, severity, and associated metabolic factors
7. Role of serum uric acid as a predictor of metabolic syndrome in overweight and obese patients
8. Comparison of insulin regimens in poorly controlled T2DM: basal-bolus vs. premixed insulin
9. Thyroid dysfunction in T2DM: prevalence, pattern, and association with glycaemic control
10. Vitamin D deficiency and insulin resistance: correlation in non-diabetic overweight individuals
11. SGLT2 inhibitor use in T2DM with CKD: real-world outcomes on eGFR and HbA1c
12. Screening for obstructive sleep apnoea in obese T2DM patients using STOP-BANG questionnaire
13. Latent autoimmune diabetes in adults (LADA): clinical features and comparison with T1DM and T2DM
14. Gestational diabetes mellitus (GDM): postpartum glucose tolerance and risk of progression to T2DM
15. Lean T2DM in India: clinical profile, C-peptide levels, and treatment response
16. Metabolic syndrome: prevalence using IDF criteria and association with cardiovascular risk scores
17. Fibrocalculous pancreatic diabetes (FCPD): clinical profile and complications in South Indian patients
18. Dyslipidaemia patterns in T2DM and correlation with HbA1c and duration of diabetes
19. Foot care knowledge and practice among T2DM patients: a cross-sectional study
20. Continuous glucose monitoring (CGM) vs. self-monitoring of blood glucose: glycaemic outcomes in T2DM

3Hypertension & Cardiovascular Thesis Topics (21–35)

21. Target organ damage in newly diagnosed hypertension: prevalence and predictors
22. White-coat hypertension vs. masked hypertension: prevalence using ambulatory blood pressure monitoring
23. Resistant hypertension: clinical profile, secondary causes, and treatment outcomes
24. Left ventricular hypertrophy in hypertensive patients: correlation with BP control and duration
25. Hypertensive crisis: clinical profile, end-organ damage, and 30-day outcome
26. Ankle-brachial index as a screening tool for peripheral arterial disease in hypertensive T2DM patients
27. Serum aldosterone-to-renin ratio in resistant hypertension: prevalence of primary aldosteronism
28. Atrial fibrillation in hypertensive patients: risk factors and CHA₂DS₂-VASc score correlation
29. Carotid intima-media thickness (CIMT) as a marker of subclinical atherosclerosis in hypertension
30. Heart failure with preserved ejection fraction (HFpEF): clinical profile and 6-month outcomes
31. Acute decompensated heart failure: precipitating factors, in-hospital management, and 90-day readmission
32. Adherence to antihypertensive therapy and its determinants: a cross-sectional study
33. Hyponatraemia in heart failure patients: incidence, severity, and impact on hospital outcomes
34. BNP/NT-proBNP as a predictor of outcome in acute decompensated heart failure
35. Cardiovascular risk assessment using Framingham Risk Score vs. WHO risk charts in hypertensive adults

4Respiratory Medicine Thesis Topics (36–50)

36. COPD exacerbation: severity assessment using DECAF score and correlation with in-hospital mortality
37. Pulmonary hypertension in COPD: echocardiographic prevalence and clinical correlates
38. Community-acquired pneumonia (CAP): PSI vs. CURB-65 scoring for severity and admission decisions
39. Drug-resistant tuberculosis (DR-TB): treatment outcomes and adverse effect profile in a tertiary centre
40. Pleural effusion: aetiology, Light's criteria performance, and diagnostic accuracy of ADA for TB
41. Obstructive sleep apnoea (OSA): prevalence in obese adults and correlation with metabolic syndrome
42. Bronchiectasis: aetiology, microbiological profile, and spirometric severity correlation
43. Interstitial lung disease (ILD): clinical, HRCT, and PFT correlation in connective tissue disease-ILD
44. Post-COVID pulmonary fibrosis: prevalence, HRCT patterns, and 6-month follow-up outcomes
45. Lung cancer: clinical profile, staging at presentation, and factors causing diagnostic delay
46. Eosinophilic lung disease: aetiology, BAL eosinophil count, and treatment response
47. Haemoptysis: aetiology, severity assessment, and outcomes in a tertiary medicine ward
48. Asthma-COPD overlap syndrome (ACOS): clinical features and spirometric profile
49. Idiopathic pulmonary fibrosis (IPF): diagnostic criteria, clinical course, and antifibrotic therapy outcomes
50. Type 2 respiratory failure: aetiology, ABG profile, and NIV outcomes in a medical ICU

5Infectious & Tropical Diseases Thesis Topics (51–70)

51. Dengue fever: clinical and laboratory predictors of severe dengue and plasma leakage
52. Scrub typhus: clinical profile, diagnostic accuracy of Weil-Felix vs. IgM ELISA, and outcomes
53. Leptospirosis: clinical spectrum, Weil's disease predictors, and antibiotic treatment outcomes
54. Malaria: clinical profile of P. vivax severe malaria and comparison with P. falciparum
55. Enteric fever: clinical features, antibiotic sensitivity patterns, and predictors of complications
56. Rickettsial infections: clinico-serological profile and response to doxycycline in a tertiary hospital
57. Tuberculosis with diabetes mellitus: clinical profile, treatment outcomes, and drug adverse effects
58. Tubercular meningitis: clinical features, CSF profile, prognostic scores, and 3-month outcomes
59. HIV-associated opportunistic infections: spectrum, CD4 count correlation, and ART outcomes
60. Klebsiella pneumoniae liver abscess: clinical features, microbiological profile, and treatment outcomes
61. COVID-19 in elderly patients: clinical profile, complications, and predictors of ICU admission
62. Post-COVID syndrome: prevalence, symptom spectrum, and quality of life at 3 and 6 months
63. Infective endocarditis: clinical profile, organism spectrum, echocardiographic findings, and surgical outcomes
64. Melioidosis: clinical presentation, culture positivity, and outcomes with meropenem therapy
65. Viral hepatitis: acute hepatitis E severity predictors and outcome in pregnancy
66. Encephalitis syndrome: aetiology (viral, autoimmune, TB), CSF profile, MRI findings, and outcomes
67. Antimicrobial resistance in bloodstream infections: organism profile, sensitivity patterns, and mortality
68. Fever of unknown origin (FUO): final diagnosis, diagnostic workup yield, and outcomes
69. Chikungunya arthritis: clinical features, anti-CCP and RF positivity, and 6-month joint outcomes
70. Sepsis and septic shock: SOFA score performance, source of infection, and 28-day ICU mortality

6Gastroenterology & Liver Disease Thesis Topics (71–85)

71. Acute liver failure: aetiology, MELD score, and predictors of spontaneous recovery vs. transplant need
72. Alcoholic hepatitis: MELD vs. Maddrey discriminant function as severity scores and corticosteroid response
73. Liver cirrhosis: Child-Pugh vs. MELD score in predicting 3-month and 6-month mortality
74. Spontaneous bacterial peritonitis (SBP): clinical profile, organism spectrum, and cefotaxime outcomes
75. Hepatic encephalopathy: precipitating factors, West Haven grading, and rifaximin treatment outcomes
76. Acute upper GI bleeding: Rockall score vs. Glasgow-Blatchford score for risk stratification
77. Helicobacter pylori prevalence in peptic ulcer disease and eradication outcomes
78. Acute pancreatitis: Ranson's criteria vs. CTSI for severity prediction and outcome correlation
79. Chronic pancreatitis: aetiology, exocrine and endocrine insufficiency, and pain management
80. Inflammatory bowel disease (IBD): clinical features, endoscopic and histological correlation in an Indian cohort
81. Drug-induced liver injury (DILI): aetiology, RUCAM score, and outcomes in a medicine ward
82. Ascites in cirrhosis: SAAG, bacterial DNA, and serum-ascites albumin gradient in diagnosis
83. Hepatorenal syndrome: type 1 vs. type 2, terlipressin response, and 30-day mortality
84. Wilson's disease: clinical spectrum in adults, ceruloplasmin levels, and chelation therapy outcomes
85. Budd-Chiari syndrome: clinical profile, thrombophilia workup, and anticoagulation outcomes

7Nephrology & Rheumatology Thesis Topics (86–100)

86. Acute kidney injury (AKI) in hospitalised medical patients: KDIGO staging, aetiology, and 30-day outcomes
87. Contrast-induced nephropathy: incidence, risk factors, and N-acetylcysteine prophylaxis outcomes
88. Lupus nephritis: ISN/RPS class, renal biopsy findings, and response to mycophenolate vs. cyclophosphamide
89. IgA nephropathy: clinico-pathological features, Oxford classification, and progression to CKD
90. Chronic kidney disease (CKD): prevalence of mineral bone disorder and correlation with PTH levels
91. Hyponatraemia in medical inpatients: aetiology, severity, and outcomes with different correction strategies
92. Hyperkalaemia in CKD: incidence, ECG changes, and treatment outcomes with patiromer/sodium zirconium
93. Rheumatoid arthritis: disease activity score (DAS28), treatment response, and cardiovascular comorbidity
94. Systemic lupus erythematosus (SLE): SLEDAI score, organ involvement pattern, and damage index at 5 years
95. Ankylosing spondylitis: BASDAI score, HLA-B27 association, and cardiovascular risk assessment
96. Gout: serum urate levels, tophi prevalence, and adherence to urate-lowering therapy
97. Vasculitis syndromes: clinical spectrum, ANCA positivity, and renal outcomes in ANCA-associated vasculitis
98. Systemic sclerosis: clinical features, ANA/anti-Scl-70 pattern, and pulmonary involvement
99. Polymyositis and dermatomyositis: clinical profile, muscle enzyme levels, and immunosuppression outcomes
100. Antiphospholipid antibody syndrome: thrombotic events, pregnancy morbidity, and anticoagulation outcomes